Research in the Cardoso lab focuses on the regulation of lung development, regeneration-repair and the role of developmental signaling in lung diseases. Ongoing studies aim to elucidate the origin of the tissue-specific stem cells of the lung and their transition to differentiate into specific lung epithelial cell types.
We investigate the mechanisms that control the organization and behavior of the airway stem cell compartment and how failure of these mechanisms leads to aberrant differentiation programs in pulmonary diseases.
Our studies on lung development focus on the regulation of cell plasticity during organogenesis and the establishment of new technologies to investigate and model diseases of prematurity in human neonates. In addition, we are using cutting-edge cellular, single-cell transcriptomics and computational approaches to study SARS-COVID-2-host interactions and identify druggable targets in the human lung.